WHEN SCIENCE MEETS TERROIR

Le Domaine Skincare was created as a marriage of Science and Terroir. Its purpose? To slow down the signs of aging.

As Marc Perrin said: “In wine, you are ultimately only as good as the land you own.” As it happens, in cosmetics too. Each of our formula is perfected like a Grand Cru, resulting in highly effective skin care where every detail serves a purpose. Whenever possible, the ingredients come directly from the Beaucastel vineyards. Owning an exceptionnal terroir gives you time to identify, capture and conduct research on potent ingredients.

The products of Le Domaine are based on more than 10 years of research by Pr. Teissedre on active ingredients derived from the Perrin Family grapevines, and more than 20 years of research by Pr. Lévy on progeria, a rare premature aging disorder, whose mechanisms are also at work in natural aging. Our formulas, all vegan, contain a minimum of 96% naturally derived ingredients, and their efficacy on the extrinsic causes of aging (responsible for 80% of the aging process), is not just claimed but all scientifically proven.

THE PROCESS OF AGING

PR. TEISSEDRE

« Wine and skin care are exact sciences » : Pr. Pierre-Louis Teissedre's life is a true testament of this vision.

Graduating from the Pharmacy School in Montpellier in 1989, he earned his PhD from the University of Montpellier. He then served as Associate Professor at the University of California Davis in the Viticulture and Enology Department. Pr. Teissedre now specializes in the phenolic compounds of grapes and grapevines. He has also authored more than 200 publications and papers in peer-reviewed international journals and is co-inventor on 13 patents.

Pr. Teissedre has worked with the Perrin family for more than 10 years, finding ways to upcycle the grape pomace recovered after making wine (and that contains unused constituents called phenolic compounds, including tannins and anthocyanins). For Le Domaine, he conducted the chemical analysis and characterization of the polyphenols from grape pomace, and was able to identify the best possible combination to create the maximum antioxidant effect.

"Oxidative stress is now recognized as the fundamental explanation for phenomena related to aging. Our goal is to control the toxic compounds from the natural oxidative stress by fighting the production of free radicals."

GSM10®: FIGHTING OXIDATIVE STRESS

GSM10® comes from studies conducted by Professor Teissedre with the laboratories of the faculty of Pharmacy of Montpellier and the research unit of the Bordeaux University. Made from a combination of marc from Grenache seeds, Syrah seeds and skins associated with a post-biotic micro-organism beneficial to the skin microbiome, this patented compound has impressively effective levels of antioxidants and anti-MMPs (matrix metallo-proteinases, such as collagenase, which destroys collagen).

GSM10® is different from active ingredients already on the market because it is created solely from natural active ingredients specific to the Rhône Valley terroir and for its patented antioxidant formulation, which is unique to Le Domaine.

Its effectiveness is very strong, as it can delay oxidation at the cellular level. It provides protection against oxidation if the product is applied regularly, and over the long term, limits skin aging.

PR. LEVY & PR. CAU

Pr. Nicolas Lévy, M.D., is a clinician and professor of human and medical genetics who has spent more than 30 years working with patients with rare diseases. He is now Chief Scientist, Rare Diseases at a leading pharmaceutical firm. For nearly 20 years, he has been researching progeria, an extremely rare genetic disorder that causes children’s bodies to age rapidly.

Through his research, Pr. Lévy has identified the mechanisms involved in progeria, which are also at work in natural skin aging - just at a far slower pace. He and Pr. Pierre Cau founded ProGeLife, a medical startup that develops treatments in the field of aging. This led them to look at some of these new molecules through the lens of skin care...

The result was a unique and exclusive patented active ingredient: ProGr3®.

"With ProGR3®, whose efficacy is not just claimed but scientifically proven, our aim is to offer benefits in the context of aging well."

PROGR3®: FIGHTING PROGERIN TOXICITY

Based on the knowledge Pr. Levy & Pr. Cau acquired treating progeria, they identified natural molecules present in plant extracts that help reduce the toxicity of progerin. They developed a combination of three molecules derived from plant extracts, Resveratrol (grapevine tendrils), Apigenin (chamomile), and Catechin (green tea). This combination from plant extracts targets Progerin, a mutated protein involved in the 12 known mechanisms responsible for cell senescence & aging.

To test the efficacy of Le Domaine products, we conducted scientific studies using the same approach as in trials evaluating therapeutic drugs. The formulas for all Le Domaine products were assessed through rigorous testing methods that combined instrumental tests and in vivo clinical trials on a large group of volunteers, conducted under dermatological supervision, with a test versus placebo. The results were astonishing. All studies demonstrated that the formula corrected skin abnormalities caused by natural aging.

A VERY STRICT BLACK LIST

The products from Le Domaine are all created, developped and made in France. They are clean, green, and conscious with a very strict blacklist excluding ingredients that are subject to controversy regarding the environment or the natural balance of your body:

- Preservatives such as parabens, phenoxyethanol, MIT, triclosan, chlorphenesin, BHA & BHT
- Silicons
- Micro plastics
- Mineral & synthetic oils
- Animal or of animal origin ingredients
- Sulphated surfactants
- EDTA

OUR MISSION: TO SLOW DOWN THE VISIBLE SIGNS OF AGING

At the core of Le Domaine Skincare is this novel, potent combination of exclusive active ingredients GSM10® and ProGR3®, that reduce the effects of progerin, which causes skin aging.

The aging process affects us all. This incontrovertible fact is what makes Le Domaine universal. More than just offering a line of anti-aging treatments, we want to help slow the process of skin aging. Our products are intentionally gender-neutral and designed for everyone, regardless of characteristics related to skin type or phenotype.

We believe that skin is an asset to be maintained, and Le Domaine wants to give, to everyone, the opportunity to age well.

OUR ICONIC PRODUCTS
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